General 
The graphical abstract is one single-panel, horizontal  (landscape orientation) rectangular image that is designed to give readers an immediate understanding of the  take-home message of the paper. It should be simple, but informative. 
            Technical requirements are as follows:  
            
              - Size: 858 × 229 pixels (X-Y axes) at 400 dpi.
 
              - Font style: Arial
 
              - Font size: 10-16
 
              - Accepted file type: PNG, JPG
 
              - Content: the abstract should summarise the       findings of the manuscript
 
              - Colours: Effective use of colour is encouraged       for increasing the aesthetic quality of the graphical abstracts and       directing the reader's attention to focal points of interest
 
              - The graphical abstracts should be drawn within a box of the indicated size (858 × 229 pixels) 
 
             
            Content 
              The graphical abstract should: 
            
              - Have a  clear start and end, "reading" from left to right
 
              - Emphasise  the take-home message of the paper 
 
              - Not  include data items of any type; all the content should be in a graphical form
 
              - Use  simple labels
 
              - The use  of text should be limited
 
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